Category: Harm Reduction

N,N-DMT Harm Reduction: How to Use & Safe Protocol

DMT is one of the strongest psychedelic compounds known to man. It is less intense than Salvia but strong in a different sense… Think of DMT as LSD, and Salvia as psilocybin (Magic Mushrooms)… DMT and LSD are more clear of headspace, whereas Salvia and psilocybin-related compounds are often very abstract and bizarre.

If you have never used any psychedelic before, then it’s possible to use DMT, but generally you will want to get used to “altered states of consciousness” first with other compounds such as LSD.

DMT can readily cause TRUE visions. The “pink elephant” LSD myth is a better descriptor for DMT… On LSD you can see true visions, but generally what you see are patterns and warping of specific objects. Visions you do have are most often “mind’s eye”, which means it’s like you’re daydreaming over the top of reality.

On the other hand, if you smoke DMT correctly in a high enough dose, you will see true visions with your two real eyes, as well as auditory hallucinations (generally a sort of alien buzzing sound – but music if you are playing any can also change). This can be overwhelming if you are not ready for this.

Testing Your DMT:

Before using your DMT, you should test it to make sure it’s what it says it is. You can do this by using reagent tests.

A good set to use are the Hofmann, Ehlrich, Marquis, and Mecke reagents. Ehrlrich detects the presence of indoles (your DMT should turn purple when the reagent is applied), while Hofmann can be more specific. With DMT, the Hofmann reagent will turn it a yellow color, whereas 5-MeO-DMT will turn green.

Meck will turn Yellow > Green > Black, while Marquis will turn Orange > Brown.

You can find full color code sheets online to help you determine what substance you are dealing with. If you need further assistance, you can post a photo of your reagent test results here:

Reagents cannot tell you with absolute certainty what is in a substance but you should at least use these before ingesting a susbtance.

For higher accuracy you will need lab testing. There are certain services which can do this for you, such as, and WEDINOS. WEDINOS is in the UK and is a free service.

Things to Remember:


  • DMT is a very strong compound, and could potentially be overwhelming to someone who is not used to the psychedelic state of mind.
  • DMT is NOT the same as 5-MeO-DMT or 4-AcO-DMT. DMT is the term for N,N-DMT specifically. 5-MeO-DMT is a substance contained within the venom of a certain species of toad and is dramatically stronger, and can cause death. 4-AcO-DMT is an orally ingested substance considered similar to Magic Mushrooms.
  • You may lose awareness of your surroundings and body, so a trip sitter is advised.
  • Do NOT fight the drug. If you are tripping on DMT, you are not able to willpower the trip away. Like a Chinese finger trap, the more you fight it the worse it gets. Surrendering yourself to the experience can help to avoid panic and bad trips.
  • It can be helpful to spend some time before smoking DMT meditating on “letting go”.
  • DO NOT smoke DMT while standing or in any position where you could fall over.
  • Music can alter the experience in a good OR bad way, silence helps to mitigate the potential for overwhelming alterations in music.
  • If you are currenlty tripping on other psychedelics (especially LSD) when you smoke DMT, the experience is likely to be tenfold more powerful. It is very likely you will “breakthrough”, and you should expect that so it does not catch you off guard.


Dangerous Combinations

If you are on SSRI medication, or anything which blocks the reuptake of serotonin or releases it, then the oral form of DMT or smoked changa (DMT with MAOI-containing herbs mixed in) is dangerous and must be avoided.

Oral DMT (Ayahuasca) contains a MAOI (monoamine oxidase inhibitor) which prevents the body from being able to break down neurotransmitters, leading to a dangerous build up of serotonin and serotonin syndrome.

Serotonin syndrome can result in sweating, confusion, delirium, seizures, coma, and even death in severe cases.

Tramadol should not be mixed with DMT because it is known to lower seizure threshold.

Amphetamines, cocaine, and cannabis are also generally not recommended to be used with DMT as they can affect the experience.

How to Use DMT Safely

If it is your first time, then a sitter is advised, and you should start with very small amounts. Do not try to eyeball the dose. Invest in some microdose spoons on Amazon (usually used for nootropics) and a scale which measures down to 0.001g.

Start at a light dose, which will be around 10mg. This should give you an idea of what the DMT experience is like without taking you too far if you decide you don’t like the way it feels.

There is not really any tolerance effect with DMT, which means you can go again after a short period unlike with other hallucinogens like LSD where you have to wait around 2 weeks between trips for tolerance to reset.

That should be noted especially so you don’t overload your smoking device believing you will have built a “tolerance” to the substance.

I advise using a vaporizer with a temperature setting. You ideally don’t want to be using flames or anything which can spill for a few reasons… First of all, the temperature for DMT vaporization is rather sensitive and without an accurate temperature it can be easy to burn the product… But in terms of harm reduction it is also important: because DMT can cause you to begin to lose sense of your surroundings and body, if you are using an open flame it would be possible to drop it or burn yourself, same if the pipe you are using allows spillage.

This can be mitigated by having a trip sitter handle the pipe and lighter for you.

But I recommend using the Storz & Bickel MIGHTY vaporizer. This is what I have experience with so I will describe how to use this device correctly.

With the vaporizer you get what are called “liquid pads”, which are semi-thick looking metallic wirey Brillo pad looking things. Once you open the vaporizer, you put this liquid pad inside.

Now, you measure out your dosage of DMT using a scale. Microdose spoons can help. What I like to do is to put some sort of small round dish type thing on top of the scale weighing part (for example, the lid of a cannabis grinder), and then put the microdose spoon propped up in there. Turn on the scale and hit “Tare” and the scale should read 0.000g.

Now, take the spoon off of the scale and scoop up a bit of DMT, and place the spoon with the DMT still on it back on top of the scale. It should give you a weight reading. When you are happy with the weight, carefully take the spoon and dump the contents onto the liquid pad inside your MIGHTY vape.

IMPORTANT: This step is very important. Do not just dump it on there and screw the top on, instead, use the back of the spoon to carefully spread the DMT around the pad. You don’t want a pile or DMT or it will not vaporize at once and you will not get a strong enough hit.

You want it spread as evenly as possible around the pad, so when it vaporizes it vaporizes all of it at once.

Now, set the temperature of your vaporizer. I find success with somewhere around 170 degrees Celsius, but some people prefer to go lower or higher. But around 165 to 175C seems to be good from my experience.

Now You’re Ready to Launch!

Make yourself comfortable, DO NOT stand while smoking this. The best thing is to be reclining in bed or on a mattress on the floor, propped up with a couple of pillows.

Make sure you feel safe and comfortable.

There is a lot of hype around the strength of DMT which can cause anxiety for a new user – however, the experience if you work up to it from lower doses should be comfortable and not as intimidating as people make it sound.

If you are using the MIGHTY vape, once it hits your set temperature it will vibrate. Now wait about 5 seconds, exhale comfortably, then begin inhaling steadily through the nozzle. The smoke will tickle but should not burn, and vaporizing it this way, it should not be as harsh as described by many who use different methods of smoking.

Keep steadily breathing in until you reach lung capacity, then hold the smoke in. Holding it for about 15 seconds seems to be good. Then exhale and go again. And again. Eventually you will reach where you want to be/will have cleared the vapor from the device.

During the inhalation it is likel you will already begin to notice changes. These changes usually first begin happening while holding in the first inhale. You will probably feel a sense of sedation at first.

Most people like to close their eyes, but you can keep them open, whichever feels right to you in the moment.

During the Experience

Your sitter should have safely taken your smoking apparatus away from you, and will be watching over you to ensure you are okay. Unlike 5-MeO-DMT, N,N-DMT is not expected to cause dangerous reactions (sort of like LSD). The main potential danger would be psychological.

You can help to prevent panic by submitting to the experience. You cannot fight it, and fighting it can make you panic. Simply let go. It can be helpful to not attempt to interpret or remember things you are experiencing, because becoming worried about “bringing things back” to tell your friends or whatever, can reduce the purity of the experience.

Generally, DMT is like a dream in the sense that when you come back from it, it’s unlikely you will remember all of it. More likely is that you will remember bits and pieces, things which particularly stood out to you.

On strong doses, the experience is indescribable in any case. Perhaps not because of the experience itself, but because it shifts so much that you don’t really have time to process something and commit it to memory before it’s shifted into another phase.

Remember, the experience WILL end, and you WILL come back to normality. Even if it really feels like you won’t, even if it feels like you’re there for eternity – these are common delusions people have while tripping which can lead to fear – they are not true. You WILL come back. So simply let go and experience it in all its purity while it lasts.